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 | | From: | Michael Reiter | | Subject: | Re: Yeast-Two-Hybrid System - Some questions | | Date: | Fri, 19 Nov 2004 08:34:38 GMT |
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 | Hi!
STAT.......Signal Transducers and Activators of Transcription
SH2.........Src Homology
Stats are the only known Transcriptionfactors containing a SH2 domain. Thus
the Signal transducing pathway is very short, since STATs are directly
activated by JAKs (Janus Kinases). Jaks are Receptors that do not
phosphorylate themselves but the STATs. Those STATs recognize each other via
their SH2 domain for Dimerization. (SH2 domains allow recognition of
tyrosinphosphates which are generated by the JAKs).
Hope this helps you!
bye
"Jorge1907" schrieb im Newsbeitrag
news:20041118171718.00480.00000841@mb-m17.aol.com...
> Mike;
>
> I can't help you but would appreciate your explaining the terms:
> STAT
> SH2
>
> There are more things in heaven and earth, Horatio,
> Than are dreamt of in your philosophy
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| | From: | Scott Coutts | | Subject: | Re: Yeast-Two-Hybrid System - Some questions | | Date: | Mon, 22 Nov 2004 10:06:34 +1100 |
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There's a lot of papers on this in medline isn't there?
Scott.
Michael Reiter wrote:
> Hi!
> STAT.......Signal Transducers and Activators of Transcription
>
> SH2.........Src Homology
>
>
> Stats are the only known Transcriptionfactors containing a SH2 domain. Thus
> the Signal transducing pathway is very short, since STATs are directly
> activated by JAKs (Janus Kinases). Jaks are Receptors that do not
> phosphorylate themselves but the STATs. Those STATs recognize each other via
> their SH2 domain for Dimerization. (SH2 domains allow recognition of
> tyrosinphosphates which are generated by the JAKs).
>
> Hope this helps you!
> bye
> "Jorge1907" schrieb im Newsbeitrag
> news:20041118171718.00480.00000841@mb-m17.aol.com...
>
>>Mike;
>>
>>I can't help you but would appreciate your explaining the terms:
>> STAT
>> SH2
>>
>>There are more things in heaven and earth, Horatio,
>>Than are dreamt of in your philosophy
>
>
>
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